Common use

Nexavar (sorafenib) is prescribed for advanced hepatocellular carcinoma (liver cancer), advanced renal cell carcinoma (kidney cancer), and differentiated thyroid carcinoma that is resistant to radioactive iodine. It works as a multikinase inhibitor, blocking enzymes that promote tumor cell growth and the formation of new blood vessels (angiogenesis) that feed tumors.

Dosage and direction

Nexavar is taken orally, usually twice daily, with or without food. Swallow tablets whole with a full glass of water. Do not crush, chew, or break the tablets. Dosage is individualized based on body weight, liver function, and tolerability. Regular monitoring of liver function, blood counts, and blood pressure is recommended.

Precautions

Inform your doctor if you have liver or kidney disease, heart problems, high blood pressure, bleeding disorders, or a history of gastrointestinal perforation. Avoid activities that increase the risk of bleeding or injury. Report any unexplained weight loss, severe diarrhea, skin changes, or unusual pain.

Contraindications

Do not use Nexavar if allergic to sorafenib or any of its components. It is contraindicated during pregnancy and breastfeeding due to risk of fetal harm. Use cautiously in patients with severe liver impairment or cardiovascular disease.

Possible side effect

Common side effects include diarrhea, fatigue, rash, hand-foot skin reactions, nausea, high blood pressure, and hair thinning. Serious side effects may include liver toxicity, bleeding, heart problems, gastrointestinal perforation, or severe allergic reactions. Seek immediate medical attention if serious symptoms occur.

Drug interaction

Nexavar may interact with anticoagulants, other cancer medications, CYP3A4 inducers/inhibitors, and certain antibiotics or antifungals. Inform your doctor of all prescription drugs, over-the-counter medications, and supplements you are taking.

Missed dose

If a dose is missed, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose.

Overdose

Overdose may cause severe diarrhea, bleeding, liver toxicity, or cardiovascular complications. Seek immediate medical attention if overdose is suspected.

Storage

Store Nexavar at room temperature, away from moisture, heat, and light. Keep tablets in the original container and out of reach of children.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.